Limitations of scale-based evaluation in structural biology, and the transition toward physical grounding, out-of-distribution generalization, and biophysical developability validation.
Jul 21, 2026
Build one graph of drugs, proteins, pathways, and a disease, embed it, and rank candidates by proximity to the disease node. Three ways of reading that ranking, then an assay.
Apr 23, 2024
Long reads span a microbial genome and short reads correct it. This note is the hybrid path from quality control through Flye, two polishing steps, and BUSCO, QUAST, Prokka, and RAST.
Jan 11, 2024