Pharmacokinetics for drug discovery
Undergraduate course, Faculty of Sciences and Techniques of Tangier, Department of Biology, 2021
Pharmacokinetics for drug discovery
- Parameters of Physical Chemistry
- Lipophilicity parameters
- Lipinski’s rule of five
- Absorption
- Dissolution
- Membrane permeation
- Computational methods for absorption estimation
- Clearance
- Renal clearance
- Hepatic clearance
- In silico methods assessing metabolism
- Toxicity
- Pharmacophore induced toxicity
- Structure related toxicity
- Metabolism induced toxicity
- Absorption